Multiple pulmonary cavitary nodules with pyoderma gangrenosum in patient with rheumatoid arthritis.
Identifieur interne : 000D64 ( Main/Exploration ); précédent : 000D63; suivant : 000D65Multiple pulmonary cavitary nodules with pyoderma gangrenosum in patient with rheumatoid arthritis.
Auteurs : Miae Be [Corée du Sud] ; Hee Jeong Cha [Corée du Sud] ; Chanho Park [Corée du Sud] ; Yongtae Park [Corée du Sud] ; Hwasik Jung [Corée du Sud] ; Yoeunim Lee [Corée du Sud] ; Yangjin Jegal [Corée du Sud]Source :
- Annals of translational medicine [ 2305-5839 ] ; 2016.
Abstract
Pyoderma gangrenosum (PG) is a rare ulcerative neutrophilic disorder of skin. Its pulmonary manifestations are uncommon and only less than forty cases have been reported in the literature previously. PG is associated with variable systemic diseases, most commonly inflammatory bowel disease and hematologic malignancies. It reported rarely in rheumatoid arthritis (RA). We report a case of PG lung involvement in patient with RA associated interstitial lung disease. A 66-year-old woman presented with productive cough and recurrent ulcerative lesion on her left ankle. She had a 15-year history of RA associated interstitial lung disease and treated with methotrexate, sulfasalazine, hydroxychloroquine and methylprednisolone. On physical examination, there were a few tender, erythematous subcutaneous nodules ranging from 1 to 3 cm in diameter on her left thigh and left elbow. Anti-neutrophil cytoplasmic antibodies (ANCAs) are negative. Her chest CT scan demonstrated multifocal cavitary consolidations on the background of reticular opacity and honeycombing. Punch biopsy of erythematous nodule on thigh showed neutrophilic abscess with necrotic debris. The skin and lung lesions were rapidly improved with 0.5 mg/kg/day of prednisolone.
DOI: 10.3978/j.issn.2305-5839.2016.01.07
PubMed: 26889492
Affiliations:
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Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>1 Department of Internal Medicine, 2 Department of Pathology, Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan</wicri:regionArea><wicri:noRegion>Ulsan</wicri:noRegion></affiliation></author><author><name sortKey="Cha, Hee Jeong" sort="Cha, Hee Jeong" uniqKey="Cha H" first="Hee Jeong" last="Cha">Hee Jeong Cha</name><affiliation wicri:level="1"><nlm:affiliation>1 Department of Internal Medicine, 2 Department of Pathology, Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>1 Department of Internal Medicine, 2 Department of Pathology, Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan</wicri:regionArea><wicri:noRegion>Ulsan</wicri:noRegion></affiliation></author><author><name sortKey="Park, Chanho" sort="Park, Chanho" uniqKey="Park C" 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Hospital, University of Ulsan, College of Medicine, Ulsan, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>1 Department of Internal Medicine, 2 Department of Pathology, Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan</wicri:regionArea><wicri:noRegion>Ulsan</wicri:noRegion></affiliation></author><author><name sortKey="Jegal, Yangjin" sort="Jegal, Yangjin" uniqKey="Jegal Y" first="Yangjin" last="Jegal">Yangjin Jegal</name><affiliation wicri:level="1"><nlm:affiliation>1 Department of Internal Medicine, 2 Department of Pathology, Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>1 Department of Internal Medicine, 2 Department of Pathology, Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan</wicri:regionArea><wicri:noRegion>Ulsan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of translational medicine</title><idno type="ISSN">2305-5839</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pyoderma gangrenosum (PG) is a rare ulcerative neutrophilic disorder of skin. Its pulmonary manifestations are uncommon and only less than forty cases have been reported in the literature previously. PG is associated with variable systemic diseases, most commonly inflammatory bowel disease and hematologic malignancies. It reported rarely in rheumatoid arthritis (RA). We report a case of PG lung involvement in patient with RA associated interstitial lung disease. A 66-year-old woman presented with productive cough and recurrent ulcerative lesion on her left ankle. She had a 15-year history of RA associated interstitial lung disease and treated with methotrexate, sulfasalazine, hydroxychloroquine and methylprednisolone. On physical examination, there were a few tender, erythematous subcutaneous nodules ranging from 1 to 3 cm in diameter on her left thigh and left elbow. Anti-neutrophil cytoplasmic antibodies (ANCAs) are negative. Her chest CT scan demonstrated multifocal cavitary consolidations on the background of reticular opacity and honeycombing. Punch biopsy of erythematous nodule on thigh showed neutrophilic abscess with necrotic debris. The skin and lung lesions were rapidly improved with 0.5 mg/kg/day of prednisolone. </div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Be, Miae" sort="Be, Miae" uniqKey="Be M" first="Miae" last="Be">Miae Be</name></noRegion><name sortKey="Cha, Hee Jeong" sort="Cha, Hee Jeong" uniqKey="Cha H" first="Hee Jeong" last="Cha">Hee Jeong Cha</name><name sortKey="Jegal, Yangjin" sort="Jegal, Yangjin" uniqKey="Jegal Y" first="Yangjin" last="Jegal">Yangjin Jegal</name><name sortKey="Jung, Hwasik" sort="Jung, Hwasik" uniqKey="Jung H" first="Hwasik" last="Jung">Hwasik Jung</name><name sortKey="Lee, Yoeunim" sort="Lee, Yoeunim" uniqKey="Lee Y" first="Yoeunim" last="Lee">Yoeunim Lee</name><name sortKey="Park, Chanho" sort="Park, Chanho" uniqKey="Park C" first="Chanho" last="Park">Chanho Park</name><name sortKey="Park, Yongtae" sort="Park, Yongtae" uniqKey="Park Y" first="Yongtae" last="Park">Yongtae Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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